Nested Case Control Study Disadvantages

Nested Case Control Study Disadvantages-38
Case-control (case-control, case-controlled) studies are beginning to appear more frequently in the neurosurgical literature.They can be more robust, if well designed, than the typical case series or even cohort study to determine or refine treatment algorithms.

This concept can be illustrated with a standard 2 × 2 table.

In a cohort study, both incidence and RR (or risk ratio) can be calculated by a/(a b) and [a/(a b)]/[c/(c d)], respectively.

These 2 groups are often mislabeled as “cases” and “controls.” A key distinction of cohort studies from case-control studies is that the former may be conducted prospectively and can answer questions about disease incidence.

This difference underlies the different types of questions that can be answered using each design.

For example, if our clinical question was focused upon whether we should be treating patients with odontoid fractures differently if they were older, our research question would be: if the patients who are treated with halo vest apparatuses and who fail to fuse are compared to the patients who do fuse within that treatment population, do those with nonunions tend to be older?

In order to address this question using a cohort study design, a large sample size would be necessary, which is prohibitive when studying rare conditions such as this.The other kind of comparative, predominantly retrospective, study with which the case-control is confused is the cohort study.This contrasts with the case-control study in that the groups treated in two different fashions are then compared for frequency of the outcome of interest.This question could be answered (in fact, most certainly would have to be answered) within a nested case-control design.This was carried out by Lennarson et al as illustrated in Figure 3.The purpose of this review is to define and explore the differences between case-control studies and other so-called nonexperimental, quasiexperimental, or observational studies in determining preferred treatments for neurosurgical patients. Impediments to the successful execution of RCTs include cumbersome study protocols, high cost, lengthy duration, and difficulty enrolling an adequate number of patients.clinical trials aimed at clinical questions outside of drugs and devices have dropped dramatically.Checklists referenced in this algorithm can be found at the Scottish Intercollegiate Guidelines Network (SIGN)Algorithm for determining study design under review for readers (including reviewers).Checklists referenced in this algorithm can be found at the Scottish Intercollegiate Guidelines Network (SIGN)Case-control studies are also differentiated by how findings are reported and the statistics used to analyze data.These studies provide an estimate of the strength of association between a variable and an outcome of interest in the form of an odds ratio (OR).If the outcome of interest is rare and both the controls and the cases are at low risk for developing the outcome, the OR can approximate the relative risk (RR) demonstrating a stronger association and inference of causality.

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Comments Nested Case Control Study Disadvantages

  • Case-Cohort Study Design STAT 507
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    Disadvantages of Case-Cohort Study as compared to nested case-control study design Increased potential for information bias because subcohort may have been established after t 0; exposure information collected at different times e.g. potential for sample deterioration Statistical Analysis for Case-Cohort Study…

  • A Nested Case-Control Study - Boston University
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    In essence, a case-control strategy was used, but it was conducted within the context of a prospective cohort study. This is referred to as a case-control study "nested" within a cohort study. Rothman states that one should look upon all case-control studies as being "nested" within a cohort.…

  • Advantages and Disadvantages of Case-Control Studies
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    Advantages and Disadvantages of Case-Control Studies Advantages They are efficient for rare diseases or diseases with a long latency period between exposure and disease manifestation.…

  • Case-control designs- Principles - InfluentialPoints
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    Case-control designs- Principles Characteristics Pros & cons. The term nested case-control study is commonly used when a case-control. Disadvantages.…

  • Case-control cont'd Flashcards Quizlet
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    It requires a more complicated statistical analysis than a nested case-control study-In studies with a long follow-up period, it is less statistically efficient than a nested case-control study-Aside This design means the OR = cumulative incidence ratio if you use incidence cases or OR = prevalence ratio if you use prevalent cases.…

  • Nested case-control studies advantages and disadvantages
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    Show full abstract Among the case-control designs, reference is made to matched and to "nested" case-control studies. These different design approaches are discussed in relation to issues of.…

  • Advantages of the nested case-control design in diagnostic.
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    Potential advantages of a nested case-control design in diagnostic research. The nested case-control study design can be advantageous over a full cross-sectional cohort design when actual disease prevalence in subjects suspected of a target condition is low, the index test is costly to perform, or if the index test is invasive and may lead to side effects.…

  • Bias in full cohort and nested case-control studies?
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    Generally, the only disadvantages to nested case-control studies are the reduced precision and power due to sampling of controls, and the possibility of flaws in the sampling design or its implementation. Therefore, any problem with nested case-control studies must also be a problem for full cohort analysis.…

  • Nested case-control studies advantages and disadvantages.
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    A nested case-control study design was used. The study design was an observational one that incorporated the concept of the traditional case-control study within an established cohort. This design overcomes some of the disadvantages associated with case-control studies,2 while incorporating some of the advantages of cohort studies.3 4…

  • Case-Control Studies - SPH
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    This is referred to as a case-control study "nested" within a cohort study. This isn't really a unique advantage to case-control studies, however, since cohort.…

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