This invited topical review, written by JCESR team members who are experts in the development and application of novel NMR methods, highlights the power of in situ and ex situ NMR for battery research.
A history of in situ NMR development and future directions are also reviewed and discussed.
Please note, we are currently updating the 2018 Journal Metrics.
This journal presents research on technical developments and innovative applications of nuclear magnetic resonance spectroscopy in the study of structure and dynamic properties of biopolymers in solution, liquid crystals, solids and mixed environments such as membranes.
We review scientific studies where nuclear magnetic resonance (NMR) proves an indispensable tool for obtaining detailed molecular level understanding of electrochemical processes for energy storage.
Featured advances include in situ NMR analyses where the chemistries within a functioning battery are probed during cell cycling.Together, NMR and MRI revolutionized the practice of chemistry and medicine by providing fast, non-destructive, and non-invasive means for the observation of matter from the atomic to the macroscopic scale. A nuclear magnetic resonance (NMR) spectrometer is the tool of choice for researchers probing chemical structures.NMR is a phenomenon that occurs when the nuclei of some, but not all, atoms in a static magnetic field and are subjected to a second oscillating electromagnetic field in the form of radio frequency radiation, which causes the nucleus to resonate.Nuclear Magnetic Resonance Laboratory The NMR Laboratory, established in 19XX by professor Maurizio Paci, is organized as a Center for Large Instruments of the University of Tor Vergata.As such, it is available to its use by internal groups of all departments and external users, both public and private.Coverage includes: Three-dimensional structure determination of biological macromolecules (polypeptides/proteins, DNA, RNA, oligosaccharides) by NMR; New NMR techniques for studies of biological macromolecules; Novel approaches to computer-aided automated analysis of multidimensional NMR spectra; Computational methods for the structural interpretation of NMR data, including structure refinement; Comparisons of structures determined by NMR with those obtained by other methods, e.g.by diffraction techniques with protein single crystals; New techniques of sample preparation for NMR experiments, such as biosynthetic and chemical methods for isotope labeling, preparation of nutrients for biosynthetic isotope labeling.Research lines presently actives at the NMR Lab: - Molecular basis of Friedreich Ataxia disease - Search for biomarkers of cardiovascular risk - Development of a Serum NMR platform for HTS metabolomics studies of population.Assessment of environmental risk and profilaxis - Characterization of the Mechanism of Action of anti-Schistosomiasi drugs - Development of new methods for drug discovery using NMR spectroscopy - Plasma Protein Binding of drug candidates using NMR - Characterization of therapeutic peptides - Study of the lipid profile of bone marrow in osteoporotic patients - Metabolomics applied to sport - Development of new compounds for the prevention of oxidative stress - Metabolomics characterization of bladder cancer - Search for enzymes working at low temperature in Antarctic’s organisms Collaborations: Departments at University of Rome “Tor Vergata” - Chemical Science and Technology - Experimental Medicine and Biochemical Science - Internal Medicine - Clinic Biochemistry - Policlinico Tor Vergata Italian Institutions and Companies - Centro Nazionale Composti Chimici e Screening, (CNCCS), consorzio pubblico privato CNR-ISS-IRBM - IRBM Science Park, Pomezia - Università di Roma “La Sapienza” - Policlinico Umberto I, Roma - Istituto di Biologia Cellulare, CNR - Istituto dei Sistemi Complessi, CNR - Facoltà di Medicina e Chirurgia, Università Vita-Salute San Raffaele, Milano - Ministero dell’Istruzione, dell’Università e della Ricerca, Programma Nazionale di Ricerche in Antartide - Bridgestone - Istituto Superiore di Sanità - Consorzio C4T International Institutions: - Università di Buenos Aires, Argentina - Istituto Fundación Leloir, Buenos Aires, Argentina - Instituto Antártico Argentino - Centro di Ingeniería Genética y Biotecnología (CIGB), l’Avana, Cuba Research Contracts (last five years): Research Contracts with CNCCS Consortium (Collezione Nazionale di Composti Chimici e Centro Screening): - “NMR Screening to select and improve potential therapeutic compounds for the treatment of Freidreich’s Ataxia”.Other researchers soon discovered the chemical shift, a small variation in NMR frequency as a result of a variation in molecular electron distribution.The ability to measure the chemical shift was a boon to chemists; it meant they could perform non-destructive chemical analyses of samples to determine molecular identity and structure much faster and more simply than before.